Your Address : Globalchemmade--Chemleader Biomedical Co.,Limited
Name:Chemleader Biomedical Co.,Limited
Type:Others
Tel:86-21-58180488
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Address:China(Mainland)
Products detail
| Product Name: | Bortezomib |
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| CAS No: | 179324-69-7 | |
| Product Type: | Pharmaceutical Intermediates | |
| Product spec: | min99% | |
| Packing: | ||
| Post Time: | 2016-07-29 | |
| Usage: | ||
| Description: | Product Name: Bortezomib Synonyms: [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-boronic acid; Velcade; DPBA CAS No.: 179324-69-7 Molecular Formula: C19H25BN4O4 Molecular Weight: 384.24 Appearance: White to off-white crystalline powder Assay: 99.5%min. Deion:Bortezomib is a ive and robust 26S proteasome inhibitor, that is a boronic acid dipeptide derivative. Human pancreatic cancer cell studies demonstrate Bortezomib to inhibit the PKR-like endoplasmic reticulum (ER) kinase and enhance ER stress, leading to apoptosis. Studies suggest that Bortezomib affects the gene expression of WT1, and blocks the function of human plasmacytoid DCs through the inhibition of intracellular trafficking of Toll-likereceptors and modification of the ER homeostasis. Additionally, Bortezomib has been reported to inhibit necrosis and cell proliferation, and downregulate metastatic gene expression. | |